Debut Biotechnology is seeking a Research Associate in downstream process development for small molecule purification. You will assist in the development of robust & scalable downstream processes, and support pilot-scale process operations to maximize product yield. This individual should have familiarity with phenomena that can be leveraged for purification on a molecular level, as well as those that can be applied for physical material separations. As such, those with backgrounds in chemistry & chemical engineering are strongly encouraged to apply. Research Associate II and Senior Research Associate level candidates will also be considered.

The successful candidate will work closely with the internal members of the downstream process development team, as well as the cross-functionally with fermentation scientists, pilot plant associates, biologists, chemists, and engineers.

Responsibilities

• Support downstream process pilot operations for robustness testing of established processes.
• Assist in bench-scale studies to support process development, optimization, & characterization.
• Coordinate with adjacent groups to ensure requirements of downstream process development are met (e.g. starting material from fermentation team, sample analysis from analytical team)
• Prepare and process samples for data analysis.
• Review, process and report data appropriately. Particular emphasis on process flow diagrams, yields, mass & energy balances.
• Document experimental studies in reports, datasheets and presentations and author/edit standard operating procedures (SOPs)
• Present experimental work to internal and external collaborators.
• Support tech transfer of developed process to allow for scale up at contract manufacturing organizations (CMOs).

Qualifications

• Bachelors/Masters degree in Chemistry, Chemical Engineering, or related subject.
• years of relevant industrial experience in downstream process development and/or purification of small molecules from complex matrices (e.g. fermentation broth).
• Attention to detail and meticulous record keeping is required.
• Experience with separation and purification technologies (centrifugation, filtration [both dead-end and cross-flow], liquid-liquid extraction, crystallization) desired.
• Experience working with pilot-scale DSP equipment a plus.
• Experience in small-scale operations / manufacturing a plus.
• Must be motivated and able to work under tight deadlines.
• Ability to work both collaboratively and independently as required.
• Strong planning, organizational, time management and communication skills.

Other

• Employment is subject to a criminal background check.
• Must be willing to work with biohazardous agents (up to BSL2).
• Work requires sufficient hand, arm, and finger dexterity to operate computer keyboard and office equipment. Laboratory operations require dexterity and care to perform studies as required.
• The R&D laboratory will result in exposure to hot and cold temperatures, noise, fumes, limited dust, and oily coolants.
• Requires walking, climbing stairs, bending and occasional lifting of material up to fifty (50) pounds.
• The performance of this position will present exposure to an industrial environment and requires support and compliance with the published Company PPE policy including but not limited to the use of personal protective equipment such as safety glasses with side shields, appropriate attire, safety shoes, hard hat, hearing protection, etc.
• Debut Biotech is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.

Salary: $65,000 - $80,000

Benefits:

• 401(k)
• 401(k) matching
• Dental insurance
• Flexible schedule
• Flexible spending account
• Health insurance
• Health savings account
• Life insurance
• Paid time off
• Parental leave
• Referral program
• Vision insurance
• Bonus pay