At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.

Associate Research Scientist In Vivo

We are seeking an Associate Research Scientist for In Vivo Pharmacology with an innovative mindset, great attention to detail and ability to work collaboratively to join our dynamic research team at Bayer Research & Innovation Center in Cambridge, MA.

This lab-based position will collaborate with the in vivo pharmacology team to study effects and dissect the mechanism of action of therapeutic lead candidates and play a key role in supporting our extensive drug discovery platform from early discovery through translational research.

In this position, you will work with in vivo oncology models and also be responsible for executing experiments to quantify molecular, cellular, and physiological readouts, in addition to supporting in vivo studies.

YOUR TASKS AND RESPONSIBILITIES

The primary responsibilities of this role, Associate Research Scientist for In Vivo are to:

• Design and execute oncology-related mouse studies to test efficacy, tolerability, PK/PD and MOA of novel oncology therapeutics with minimal supervision and deliver comprehensive high quality data sets to help decision-making;
• Perform animal dosing, sacrifice, biopsy or tissue collection, sample processing and ex vivo analysis;
• Establish and maintain in vivo disease models (CDX, PDX and syngeneic tumor models);
• Assist in IACUC animal protocol development and animal ordering;
• Collect, analyze, interpret data and maintain thorough electronic lab notebooks and documentation records;
• Ensure that laboratory notebooks are consistently updated, audited, and well maintained;
• Present study observations and data within cross-functional program meetings as well as all company scientific meetings;
• Assist in external collaborations with CROs.

WHO YOU ARE

Your success will be driven by your demonstration of our LIFE values. More specifically related to this position, Bayer seeks an incumbent who possesses the following:

Required Qualifications:

• Bachelor of Sciences Degree;
• Proficiency with in vivo oncology models, including CDX, PDX and syngeneic tumor models;
• Proficiency with caliper measurements and clinical scoring endpoints to evaluate pre-clinical anti-cancer therapies;
• Hands-on experience with small animal imaging modalities, i.e., bioluminescence (BLI) and/or nuclear imaging (PET/SPECT);
• Demonstrated ability with blood collection (via different routes, i.e., tail vein, submandibular, cardiac puncture), necropsy, and tissue collection;
• Demonstrated ability for drug administration by multiple routes (PO, IV, IP, SQ, IT);
• Working knowledge of fundamental molecular biology techniques applicable to ex vivo tissue analysis;
• Detail-oriented, highly organized, with excellent oral and written communication skills; Holding high standard of scientific integrity;
• Independence with routine laboratory work, and enthusiasm for learning new research methods/techniques.

Preferred Qualifications:

• Bachelor of Sciences with at least six years relevant experience or Master of Science with at least four years relevant experience or equivalent combination of education and experience;
• Hands-on experience in orthotopic tumor modeling and aseptic surgery techniques (e.g., castration);
• Experience with Western blot, ELISA, flow cytometry, qPCR, RT-qCR, MSD, in situ Hybridization (ISH), RNAscope and other standard cell-based and non-cell based biochemical assays;
• Experience in Mammalian cell culturing and maintaining human tumor cell lines and primary human cells;
• Working knowledge of data management and statistical analysis (Graph Pad Prism, Office 365, etc);
• Knowledge of gene therapy or gene editing techniques.

#LIUS